Frisco No. 1621 is a type of 2-10-0 Decapod steam locomotive. It was built in 1918 by the Baldwin Locomotive Works for the Russian Government as a broad gauge (5 foot gauge) engine, but due to the Russian Revolution it was kept in the USA. It was converted to standard gauge, and given to the Pennsylvania Railroad, before being purchased by the St. Louis–San Francisco Railway. It was assigned as a mixed traffic engine when it was owned by the St. Louis–San Francisco Railway until the end of the steam in the 1950's. After it's withdrawal it was sold to Eagle-Picher who used it to haul lead ore to a smelting plant.

Today, this steam locomotive is on static display at The Museum of Transportation in Kirkwood, Missouri.